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KMID : 0359819930220080877
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Journal of Korean Neurosurgical Society
1993 Volume.22 No. 8 p.877 ~ p.883
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The Effect of Halothane induced Acidosis on Focal Cerebral Ischemia in Rat
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Abstract
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The current study was performed to investigate the influence of acidosis on focal cerebral ischemia in view of morphometric assay and neuropathological examination. The acidosis was induced by increment of halothane concentration and by
decreasing
respiratory rate. The mean pH were 7.423±0.012 in control group and 7.184±0.038 in acidosis group. Twenty-four hours after MCA occlusion (MCAO). Neutral red staining and perfusion fixation was performed. The ischemic area was measured and
morphometric
analysis was undertaken. In acidosis group, the infarct area was 25.23±4.78% of the total cerebral area ; in control group, the infarct area was 27.69±4.05%. The histopathological findings were examined under light microscopy, in which the
ficld
scanning was carried out from the midline by 0.5mm interval at cortical and basal ganglia levels. These results indicated that although there was no satistically significant difference in infarct area between acidosis and control group, increased
acidosis aggravated the extent of histopathologic ischemic neuronal damage.
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KEYWORD
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